(The) Children of Men
The novel, published in 1992, posits that human fertility comes to an end in 1995 and the main action is set in 2021, when the 25-year-old youngest human dies. The 2006 film has the infertility starting in 2009 and sets the action in 2027, when the 18-year-old youngest human dies.
In the novel, Theo had had a wife, Helena, and meets a female activist, Julian. In the film, Julian had been, probably not his wife, but his 'partner' and had borne him a child. In both cases, the child is killed young - in the novel Theo runs over her accidentally, in the film by a 'flu pandemic.
The film works towards a denouement involving very violent scenes of street-fighting - Falluja replayed on the streets of Bexhill-on-Sea. Among the cuttings and so on that a character pastes on his wall as reminders of the past, there are handbills reading 'Don't attack Iraq' and 'Stop the war'. And, of course, Theo and Julian met at a 'demonstation where there were a million people.'
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